导师信息

邵诗颖

院系名称:同济医院

担任职务:

专业职称:副教授,副主任医师

导师类别:硕士生导师

导师代码:

一级学科码: 1002        一级学科名称: 临床医学

二级学科码:       二级学科名称:内科学

研究方向

糖尿病及甲状腺相关疾病

所在科室

内分泌与代谢病

个人简介

华中科技大学同济医院内分泌科,副教授,副主任医师,医学博士。任《中国循证医学杂志》青年编委,任中华医学会糖尿病学分会糖尿病与相关内分泌疾病学组组员。

教育与工作经历

大学开始受教育经历
1999.9-2006.7,同济医科大学同济医学院,临床医学硕士学位,导师:邹萍教授
2006.9-2009.10,新加坡国立大学, Ph.D,导师:Prof. Li Guodong
研究工作经历
2015/11-至今,华中科技大学,同济医院,副教授
2009/10-2015/11,华中科技大学,同济医院,讲师,主治医师
2013/10-2014/10,瑞士苏黎世联邦理工学院,IMSB,访问学者

已结题科研项目

1. 国家自然科学基金青年项目,81100581,SREBP-1c在饱和/不饱和脂肪酸相关β细胞功能受损/保护的体内外研究,2012/01-2014/12,23万元,已结题,主持
2. 中华国际医学交流基金,利拉鲁肽在肥胖2型糖尿病自身免疫所致β细胞受损中的保护效应与机制研究,2015/01-2016/12,10万,已结题,主持
3. 中华国际医学交流基金,GLP-1在脂毒性所致β细胞受损中的保护效应及机制研究,2011/01-2012/12,10万,已结题,主持
4. 华中科技大学自主创新基金,0118540208,Exenatide在1型糖尿病自身免疫所致β细胞受损中的保护效应,2015/01-2016/12,5万,已结题,主持
5. 华中科技大学教学研究项目,CBL, PBL与TBL整合教学法在内分泌学科中的实践,2015/08-2016/09,1万,已结题,主持

在研项目

1. DBPR108片单药治疗2型糖尿病的多中心、随机、双盲双模拟、安慰剂平行对照的II期临床试验, 2018/01-2019/12, 24.8万,在研,主持
2. 曲美他嗪在糖尿病周围动脉疾病中的临床疗效及分子机制, 2018/01-2019/12, 5万,在研,主持
3. 二甲双胍改善Th17/ Treg细胞失衡介导的2型糖尿病脂毒性的机制探讨, 3万,在研,主持

指导的研究生获得奖励

代表学术论文

1. Shao S (邵诗颖),Yu X, Shen L. Autoimmune thyroid diseases and Th17/Treg lymphocytes. Life Sciences. 2017
2. Shao S (邵诗颖), Xu W, Tao J, Zhang J, Zhou X, Yuan G, Yang Y, Zhang J, Yu X. Glycemic Index, Glycemic Load, and Glycemic Response to Pomelo in Patients with Type 2 Diabetes. J Huazhong Univ Sci Technol [Med Sci]. 2017 37 (5):711-718.
3. Li X, Wang J, Yang Q, Shao S* (邵诗颖co-correspondence). 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Subjects With Type 2 Diabetes Mellitus. Am J Med Sci. 2017 Oct; 354(4):408-414.
4. Chen C, Yang Y, Yu X, Hu S, Shao S (邵诗颖correspondence). Association between omega-3 fatty acids consumption and the risk of type 2 diabetes: A meta-analysis of cohort studies. J Diabetes Investig. 2017 Jul 8(4):480-88.
5. Shao S (邵诗颖), Zhang X, Zhang M. Inhibition of 11β-hydroxysteroid dehydrogenase type 1 ameliorates obesity-related insulin resistance. Biochem Biophys Res Commun. 2016 Sep 9;478(1):474-80.
6. Shao S (邵诗颖), Guo T, Gross V, Lazarev A, Koh CC, Gillessen S, Joerger M, Jochum W, Aebersold R. Reproducible Tissue Homogenization and Protein Extraction for Quantitative Proteomics Using MicroPestle-Assisted Pressure-Cycling Technology. J Proteome Res. 2016 15(6):1821-9
7. Yang Y, Ma D, Xu W, Chen F, Du T, Yue W, Shao S * (邵诗颖, co-correspondence), Yuan G*. Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level. Mol Cell Neurosci. 2016 Jan;70:68-75.
8. Shao S (邵诗颖), Guo T, Koh CC, Gillessen S, Joerger M, Jochum W, Aebersold R. Minimal sample requirement for highly multiplexed protein quantification in cell lines and tissues by PCT-SWATH mass spectrometry. Proteomics. 2015 Nov;15(21):3711-21.
9. Chen C, Yu X, Shao S (邵诗颖 correspondence). Effects of Omega-3 Fatty Acid Supplementation on Glucose Control and Lipid Levels in Type 2 Diabetes: A Meta-Analysis. PLoS One. 2015 Oct 2;10(10):e0139565.
10. Shao S (邵诗颖), Guo T, Aebersold R. Mass spectrometry-based proteomic quest for diabetes biomarkers. BBA Proteins and Proteomics. 2015 Jun;1854(6):519-27.
11. Shao S (邵诗颖). Protective Action of Liraglutide in Beta Cells Under Lipotoxic Stress Via PI3K/Akt/FoxO1 Pathway. J Cell Biochem. 2014, 115(6):1166-75.
12. Yang Yan, Zhang J, Ma D, Zhang M, Hu S, Shao S* (邵诗颖, co-correspondence), Gong CX*. Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes. J Alzheimers Dis. 2013, 37(3):637-48.
13. Shao S (邵诗颖), Li X. Clinical features and analysis in 1385 Chinese patients with pituitary adenomas. J Neurosurg Sci. 2013, 57(3):267-75.
14. Shao S (邵诗颖), Yang Y, Yuan G, Zhang M, Yu X. Signaling molecules involved in lipid-induced pancreatic Beta-cell dysfunction. DNA Cell Biol. 2013, 32 (2):41-9.
15. Shao S (邵诗颖), He F, Yang Y, Yuan G, Zhang M, Yu X. Th17 cells in type 1 diabetes. Cell Immunol. 2012, 280 (1):16-21.
16. Shao S (邵诗颖), Gao Y, Xie B, Xie F, Lim SK, Li G. Correction of Hyperglycemia in Type 1 Diabetic Models by Transplantation of Encapsulated Insulin-producing Cells Derived from Mouse Embryo Progenitor. J Endocrinol. 208 (2011): 245-255.
17. Shao S (邵诗颖), Liu Z, Yang Y, Zhang M, Yu X. SREBP-1c, Pdx-1, and GLP-1R involved in palmitate-EPA regulated glucose-stimulated insulin secretion in INS-1 cells. J Cell Biochem. 111 (2010): 634-642.
18. Shao S (邵诗颖), Zhang M, Yu X. Transcription factors involved in glucose-stimulated insulin secretion of pancreatic beta cells. BiochemBiophys Res Commun. 374 (2009): 401-404.

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