导师信息

王涛

院系名称:附属同济医院

担任职务:

专业职称:教授、副主任医师

导师类别:博士生导师

导师代码:3708

一级学科码: 1002        一级学科名称: 临床医学

二级学科码:100210       二级学科名称:外科学

研究方向

1.男科学 2.前列腺癌 3.泌尿系结石

所在科室

外科学(泌尿外)

个人简介

医学博士、教授、副主任医师、博士生导师。
临床方面擅长泌尿男科疾病、泌尿系肿瘤、泌尿系结石的诊治,能熟练开展泌尿外科常规手术、微创手术、显微泌尿男科手术和机器人手术。如机器人/腹腔镜肾、肾上腺、前列腺、膀胱手术,经尿道、经皮碎石取石术,经尿道膀胱肿瘤、前列腺切除术等,尤其钻研了男科机器人及显微手术(机器人/显微镜下附睾管输精管或输精管输精管吻合术、显微精索静脉结扎术等)及精囊镜手术。
一直致力于泌尿男科疾病的基础与临床研究工作,截止2017年发表SCI论文总影响因子150余分,其中第1作者或通讯作者论文20余篇,总影响因子60余分,单篇影响因子最高9.619;目前已被16本国际一流SCI杂志(影响因子最高8.395)邀请审稿。
入选武汉市中青年医学骨干人才(第四批),是同济医院优秀共产党员,《医学参考报泌尿外科与男科学频道》编委,《中华实验外科杂志》、《中华男科学杂志》、《临床泌尿外科杂志》、《现代泌尿生殖肿瘤杂志》通讯编委。

教育与工作经历

1995.9~2000.7:华中科技大学同济医学院医疗二系学生,获医学学士学位
2000.9~2002.7:华中科技大学同济医学院附属同济医院小儿外科研究生,获医学硕士学位(免试)
2002.9~2005.7:华中科技大学同济医学院附属同济医院泌尿外科研究生,获医学博士学位(免试)
2004.07~2004.10:华中科技大学同济医学院附属同济医院泌尿外科住院医师
2005.01~2005.06:华中科技大学同济医学院附属同济医院泌尿外科总住院医师
2005.07~2010.11:华中科技大学同济医学院附属同济医院泌尿外科主治医师
2010.11~2011.11:华中科技大学同济医学院附属同济医院泌尿外科副主任医师(内聘)
2011.11~2012.03:华中科技大学同济医学院附属同济医院泌尿外科副主任医师、副教授
2012.03~2016.11:华中科技大学同济医学院附属同济医院泌尿外科副主任医师、副教授、硕士生指导老师
2016.11~2017.11:华中科技大学同济医学院附属同济医院泌尿外科主任医师(内聘)、教授、硕士生指导老师
2017.11~ 华中科技大学同济医学院附属同济医院泌尿外科主任医师(内聘)、教授、博士生指导老师

已结题科研项目

2010.1~2012.12: “VKORC1通过维生素K循环影响草酸钙尿石形成的机制研究(No.30901482)” 国家自然科学基金课题,20.0万,课题负责人。
2011.1~2013.12:“PDE5和iNOS基因修饰的自体脂肪干细胞移植治疗勃起功能障碍(No:81070484)”国家自然科学基金课题,33.0万,课题组排名第二。
2011.1~2013.12:“CAMK2N1介导雄激素受体对前列腺癌抑制作用的机制研究(No:81001133)”国家自然科学基金课题,19.0万,课题组排名第二。
2009.1~2011.12:“RNA激活技术治疗勃起功能障碍的实验研究(No: 30872574)”,国家自然科学基金课题,34.0万,课题组排名第二。
2012.5~2014.5 “miR-145参与高脂血症勃起功能障碍发病的机制研究(No: 18540018)”,2012年华中科技大学自主创新基金课题,4.0万,课题负责人。
2011.1~2012.1: “ Functional and morphological improvement in erectile tissue of diabitic rats by long-term low-dose treatment of sidenafil”, pfizer asia urology grant ,13.5万,课题负责人。
2006.9~2008.8:“增龄对大鼠阴茎组织中激肽释放酶系统表达的影响”,2006年同济医院科研基金课题,1.0万,课题负责人。
2006.1~2006.12:“The effect of siRNAs targeted PDE5 gene on the erectile function in rats”,the research grant of the Asia Pacific Society for Sexual & Impotence Research, USD 5000. 课题组排名第二。
2005.1~2006.12:“利用正电子发射断层成像(PET)技术研究人类勃起反应的中枢机制”,2004年华中科技大学医工、医理学科交叉科研基金课题,1.5万,课题组排名第二。
2005.6~2006.7:“评价达泊西汀在治疗早泄中的疗效与安全性的随机、双盲、安慰剂对照、国际多中心临床试验”,(方案号:R096769-PRE-3003),课题组排名第二。
2004.9~2006.9: “电子射精仪电刺激诱导射精治疗不射精症”,2004年同济医院新业务新技术基金课题,2.0万,课题组排名第二。

在研项目

2016.1~2019.12:“DNMT1/CAMK2N1反馈调节及其介导的甲基化修饰在前列腺癌去势抵抗中的作用机制研究(No: 81572539)”国家自然科学基金课题,78.0万,课题负责人。
2015.1~2018.12:“AR/miRNA-190/YB-1负反馈循环机制及对前列腺癌抑制作用的生物学研究(No: 81472405)”国家自然科学基金课题,80.0万,课题组排名第二。

指导的研究生获得奖励

代表学术论文

1. Li H, Chen LP, Yang J, Li MC, Chen RB, Lan RZ, Wang SG, Liu JH, Wang T.Predictive value of FSH, testicular volume, and histopathological findings for the sperm retrieval rate of microdissection TESE in nonobstructive azoospermia: a meta-analysis. Asian J Androl. 2017 Mar 24.[Epub ahead of print]
2. Wang T, Cai Y, Song W, Chen R, Hu D, Ye J, Liu L, Peng W, Zhang J, Wang S, Yang W, Liu J, Ding Y.Ethyl Acetate Extracts of Semen Impatientis Inhibit Proliferation and Induce Apoptosis of Human Prostate Cancer Cell Lines through AKT/ERK Pathways.Biomed Res Int. 2017;2017:1243515. IF=2.476
3. Chen Z, Liu Q, Chen R, Liu Z, Li M, Ling Q, Wu L, Yang J, Liu X, Wang T, Hu Z, Guo X, Wang S, Yang W, Liu J.Clinical analysis of small cell carcinoma of the bladder in Chinese: nine case reports and literature reviews.World J Surg Oncol. 2017 Jan 26;15(1):33. IF=1.600
4. Liu Z, Jiang H, Yang J, Wang T, Ding Y, Liu J, Wang S, Ye Z.Analysis of altered microRNA expression profiles in the kidney tissues of ethylene glycol-induced hyperoxaluric rats. Mol Med Rep. 2016; 14(5):4650-58. (*As corresponding author) IF=1.692
5. Wang T, Song W, Chen Y, Chen R, Liu Z, Wu L, Li M, Yang J, Wang L, Liu J, Ye Z, Wang C, Chen K. Flightless I Homolog Represses Prostate Cancer Progression through Targeting Androgen Receptor Signaling.Clin Cancer Res. 2016 ;22(6):1531-44. IF=9.619
6. Chen R, Luan Y, Liu Z, Song W, Wu L, Li M, Yang J, Liu X, Wang T, Liu J, Ye Z. AR Pathway Is Involved in the Regulation of CX43 in Prostate Cancer. Biomed Res Int. 2015;2015:514234. (*As corresponding author) IF=2.476
7. Li MC, Wang ZY, Yang J, Guo XL, Wang T*, Wang SG, Liu JH*, Ye ZQ.Efficacy and safety of solifenacin plus tamsulosin oral controlled absorption system in men with lower urinary tract symptoms: a meta-analysis. Asian J Androl. 2015;17(1):124-34. (*As corresponding author) IF=2.996
8. Wang T, Guo S, Liu Z, Wu L, Li M, Yang J, Chen R, Liu X, Xu H, Cai S, Chen H, Li W, Xu S, Wang L, Hu Z, Zhuang Q, Wang L, Wu K, Liu J, Ye Z, Ji JY, Wang C, Chen K.CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.Oncotarget. 2014;5(21):10293-306. IF=5.168
9. Wang T, Liu Z, Guo S, Wu L, Li M, Yang J, Chen R, Xu H, Cai S, Chen H, Li W, Wang L, Hu Z, Zhuang Q, Xu S, Wang L, Liu J, Ye Z, Ji JY, Wang C, Chen K.The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer.Oncotarget. 2014;5(11):3611-21. IF=5.168
10. Wang T, Li M, Yuan H, Zhan Y, Xu H, Wang S, Yang W, Liu J, Ye Z, Li LC.saRNA guided iNOS up-regulation improves erectile function of diabetic rats.J Urol. 2013 Aug;190(2):790-8. IF=5.157
11. Yang J, Wang T*, Yang J, Rao K, Zhan Y, Chen RB, Liu Z, Li MC, Zhuan L, Zang GH, Guo SM, Xu H, Wang SG, Liu JH, Ye ZQ.S-allyl cysteine restores erectile function through inhibition of reactive oxygen species generation in diabetic rats.Andrology(incorporated by Journal of Andrology and International Journal of Andrology). 2013 May;1(3):487-94. (*As corresponding author) IF=2.427
12. Li M, Liu Z, Zhuan L, Wang T*, Guo S, Wang S, Liu J*, Ye Z.Effects of apocynin on oxidative stress and expression of apoptosis-related genes in testes of diabetic rats.Mol Med Rep. 2013 Jan;7(1):47-52. Epub 2012 Oct 17. (*As corresponding author) IF=1.692
13. Li M, Wang T*, Guo S, Rao K, Liu J*, Ye Z.Expression of oxytocin receptor in diabetic rat penis.Andrologia. 2012 May;44 Suppl 1:716-20. (*As corresponding author) IF=1.458
14. Li M, Zhuan L, Wang T*, Rao K, Yang J, Yang J, Quan W, Liu J*, Ye Z.Apocynin improves erectile function in diabetic rats through regulation of NADPH oxidase expression.J Sex Med. 2012 Dec;9(12):3041-50. Epub 2012 Oct 22. (*As corresponding author) IF=2.978
15. Liu Z, Wang T*,Yang J, Wang S,Yang W, Liu J, Ye Z. Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor β1 expression in human renal epithelial cells. Mol Med Rep. 2012 May;5(5):1241-4. (*As corresponding author) IF=1.692
16. Liu Z, Li M, Chen K, Yang J, Chen R, Wang T*, Liu J, Yang W, Ye Z.S-allylcysteine induces cell cycle arrest and apoptosis in androgen-independent human prostate cancer cells.Mol Med Report. 2012 Feb;5(2):439-43. (*As corresponding author) IF=1.692
17. Hu B, Wang T*, Liu Z, Guo X, Yang J, Liu J*, Wang S, Ye Z.Decreased expression of vitamin K epoxide reductase complex subunit 1 in kidney of patients with calcium oxalate urolithiasis.J Huazhong Univ Sci Technolog Med Sci. 2011 Dec;31(6):807-14. (*As corresponding author) IF=0.838
18. Chen RB, Wang T*, Rao K, Yang J, Zhang SL, Wang SG, Liu JH*, Ye ZQ. Up-regulation of VEGF by Small Activator RNA in Human Corpus Cavernosum Smooth Muscle Cells. J Sex Med. 2011 Oct;8(10):2773-80. (*As corresponding author). IF=2.844
19. Wang T, Wan ZH, Liu JH, Chen MY, Chen RB, Yang WM, Ye ZQ.Age-related changes in kallikreins-kinins system in rat corpus cavernosum. Int J Androl. 2011;34(1):33-40. IF=3.206
20. Wang T, Yang J, Qiao J, Liu J, Guo X, Ye Z.Activity and Expression of Vitamin K-Dependent Gamma-Glutamyl Carboxylase in Patients with Calcium Oxalate Urolithiasis. Urol Int. 2010;85(1):94-99 . IF=1.292
21. Wang T, Chen R, Qiao J, Hu T, Liu J, Yang W, Ye Z. Solitary fibrous tumor in bladder: A case report.J Huazhong Univ Sci Technolog Med Sci. 2010 Jun;30(3):412-4. IF=0.838
22. Wang T, Liu JH, Yang J, Chen J, Ye ZQ.46, XX male sex reversal syndrome: a case report and review of the genetic basis. Andrologia. 2009;41(1):59-62. IF=1.441
23. Zhang Y, Chen Z, Wang T, et al. Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase. Oncotarget. 2016:7(26):39302-39315. IF=5.008
24. Li R, Meng X, Zhang Y, Wang T, Yang J, Niu Y, Cui K, Wang S, Liu J, Rao K: Testosterone improves erectile function through inhibition of reactive oxygen species generation in castrated rats. PeerJ.2016 May 3;4. IF=2.183
25. Xu S, Tao Z, Hai B, Liang H, Shi Y, Wang T, Song W, Chen Y, OuYang J, Chen J, Kong F, Dong Y, Jiang SW, Li W, Wang P, Yuan Z, Wan X, Wang C, Li W, Zhang X, Chen K: miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint. Nat Commun 2016;7:11406. IF=11.329
26. Li M, Li H, Ruan Y, Wang T, Liu J: Stem Cell Therapy for Diabetic Erectile Dysfunction in Rats: A Meta-Analysis. PLoS One 2016;11:e0154341. IF=3.057
27. Xu S, Wang T, Song W, Jiang T, Zhang F, Yin Y, Jiang SW, Wu K, Yu Z, Wang C, Chen K.The inhibitory effects of AR/miR-190a/YB-1 negative feedback loop on prostate cancer and underlying mechanism.Sci Rep. 2015 Aug 28;5:13528. IF=5.228
28. Sun X, Jiang S, Liu J, Wang H, Zhang Y, Tang SC, Wang J, Du N, Xu C, Wang C, Qin S, Zhang J, Liu D, Zhang Y, Li X, Wang J, Dong J, Wang X, Xu S, Tao Z, Xu F, Zhou J, Wang T, Ren H.MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1.Oncotarget. 2015 Oct 20;6(32):32944-54. IF=5.008
29. Xu H, Niu Y, Wang T, Liu S, Xu H, Wang S, Liu J, Ye Z.Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate. Biomed Res Int. 2015;2015:649698.Epub 2015 Jun 25. IF=2.134
30. Lv ZT, Song W, Wu J, Yang J, Wang T, Wu CH, Gao F, Yuan XC, Liu JH, Li M.Efficacy of Acupuncture in Children with Nocturnal Enuresis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Evid Based Complement Alternat Med. 2015;2015:320701. Epub 2015 Jun 16. IF=1.931
31. Xu H, Li Z, Wang T, Wang S, Liu J, Wang DW.Novel homozygous deletion of segmental KAL1 and entire STS cause Kallmann syndrome and X-linked ichthyosis in a Chinese family.Andrologia. 2015 Dec;47(10):1160-5. IF=1.441
32. Li M, Wang Z, Yang J, Guo X, Wang T, Wang S, Yin C, Liu J, Ye Z.Adjunctive medical therapy with α-blocker after extracorporeal shock wave lithotripsy of renal and ureteral stones: a meta-analysis.PLoS One. 2015 Apr 10;10(4):e0122497. IF=3.057
33. Zhang S, Wang T, Yang J, Liu Z, Wang S, Liu J.A fertile male patient with Kallmann syndrome and two missense mutations in the KAL1 gene. Fertil Steril. 2011 Apr;95(5):1789.e3-6. Epub 2010 Dec 18. IF=4.426
34. Xiao HJ, Wang T, Chen J, Fan LC, Yin CP, Liu JH, Gao X.Chuanxiongzine relaxes isolated corpus cavernosum strips and raises intracavernous pressure in rabbits. Int J Impot Res. 2010;22(2):120-6. IF=1.396
35. Qiao J, Wang T, Yang J, Liu J, Gong X, Guo X, Wang S, Ye Z.Genetic mutation of vitamin K-dependent gamma-glutamyl carboxylase domain in patients with calcium oxalate urolithiasis. J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):604-8. IF=0.838
36. Liu J, Wang T, Chen J, Wang S, Ye Z. Decreased inhibitory activity of prothrombin to calcium oxalate crystallization by specific chemical modification of its gamma-carboxyglutamic acid residues.Urology,2006,67(1):201-203. IF=2.187
37. Zhang SL, Tang YP, Wang T, Yang J, Rao K, Zhao LY, Zhu WZ, Meng XH, Wang SG, Liu JH, Yang WM, Ye ZQ.Clinical assessment and genomic landscape of a consanguineous family with three Kallmann syndrome descendants. Asian J Androl. 2011 Jan;13(1):166-71. Epub 2010 Nov 1. IF=2.644
38. Chen J, Liu J, Wang T, Xiao H, Yin C.Effects of tetrandrine on cAMP and cGMP levels in rabbit corpus cavernosum in vitro.Nat Prod Res. 2010 Jul;24(12):1095-103. IF=1.693
39. Chen J, Liu J, Wang T, Xiao H, Yin C, Yang J, Chen X, Ye Z.The relaxation mechanisms of tetrandrine on the rabbit corpus cavernosum tissue in vitro.Nat Prod Res. 2009;23(2):112-21. IF=1.693
40. Chen K, Hu Z, Wang T, Guo H, Ye Z. Inhibitory effect of matrine on the expression of PSA and AR in prostate cancer cell line LNCaP. J Huazhong Univ Sci Technolog Med Sci. 2008;28(6):697-9. IF=0.838
41. Chen J, Liu JH, Wang T, Xiao HJ, Yin CP, Yang J. Effects of plant extract neferine on cyclic adenosine monophosphate and cyclic guanosine monophosphate levels in rabbit corpus cavernosum in vitro.Asian J Androl. 2008 ;10(2):307-12. IF=2.644
42. Liu JH, Chen J, Wang T, Liu B, Yang J, Chen XW, Wang SG, Yin CP, Ye ZQ. Effects of tetrandrine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbits. Asian J Androl, 2006, 8(4):405-409. IF=2.644
43. Liu J, Chen J, Wang T, Wang S, Ye Z. Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus. J Urol, 2005,173(1):113-116. IF=4.7
44. Chen J, Qi J, Chen F, Liu JH, Wang T, Yang J, Yin CP. Relaxation mechanisms of neferine on the rabbit corpus cavernosum tissue in vitro. Asian J Androl. 2007 ,9(6):795-800. IF=2.644
45. Chen J, Liu JH, Jiang ZJ, Wang T, Liu B, Yang J, Yin CP, Chen F. Effects of neferine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbits. Andrologia,2007,39(4):141-145. IF=1.441
46. Xiao H, Liu J, Yin C,Wang T,Chen J, Fan L, Ye Z. Effects of Ligustrazine on the contraction of isolated rabbit corpus cavernosum strips. Journal of Huazhong University of Science and Technology[Med Sci], 2005,25(5):565-567. IF=0.838
47. Liu J, Liang P, Yin C, Wang T, Li H, Li Y, Ye Z. Effects of several Chinese herbal aqueous extracts on human sperm motility in vitro. Andrologia. 2004 Apr;36(2):78-83. IF=1.441
48. Liu G, Yuan J, Feng J, Geng J, Zhang W, Zhou X, Wang T. Factors affecting the long-term results of hypospadias repairs. J Pediatr Surg, 2006,41(3):554-559. IF=1.733

获奖情况

1. Excellence in Reviewing,SPANDIDOS PUBLICATIONS, 2017年4月
2. 武汉市中青年医学骨干人才(第四批),武汉市卫生和计划生育委员会,2016年8月
3. 中国十大优秀青年男科医师,中国医师协会,2015年9月
4. 2010~2011年度同济医院优秀共产党员,2011年6月

E-mail

twang@tjh.tjmu.edu.cn

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